Details of Dasatinib Salt (Generic Drug)

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Details

Dasatinib is a cancer medicine that slows the growth and spread of cancer cells in the body. Dasatinib is used to treat chronic myeloid leukaemia (CML) and acute lymphoblastic leukaemia (ALL) when other cancer treatments have not been effective. Some people using dasatinib have developed a rare but serious condition called pulmonary arterial hypertension (PAH). PAH occurs when blood pressure increases inside the arteries in your lungs. To make sure dasatinib is safe for you, tell your doctor if you have a weak immune system (caused by disease or by using certain medicine) liver disease heart disease a personal or family history of Long QT syndrome lung disease or low levels of potassium or magnesium in your blood. Dasatinib tablets contain lactose. Talk to your doctor before using this medicine if you are lactose-intolerant. Do not use dasatinib if you are pregnant.


Typical Uses

Dasatinib is used to treat certain types of cancer (chronic myeloid leukaemia and acute lymphoblastic leukaemia). It works by slowing or stopping the growth of cancer cells. Since dasatinib can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets. Dasatinib may affect fertility (your ability to have children), whether you are a man or a woman.


Side Effects

Inform your doctor if you have any symptoms of pulmonary arterial hypertension (PAH), such as feeling tired or short of breath (even with mild exertion) swelling in your feet or lower legs blue-coloured lips and skin and a light-headed feeling, like you might pass out. Some of the other side effects of dasatinib include pain when you breathe, rapid heart rate, feeling short of breath (especially when lying down) pain in your chest, on your left side, or behind your breastbone rapid weight gain (especially in your face and midsection) low platelets or red blood cells-pale skin, feeling light-headed, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin low white blood cell counts-fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough or other signs of bleeding-bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds, confusion, headache, problems with speech, extreme weakness or drowsiness.


Drug Interactions

• Dasatinib+abciximab- Using dasatinib together with abciximab may increase the risk of bleeding. The interaction may be more likely if you are elderly or have kidney or liver disease. In clinical studies, treatment with dasatinib alone has been associated with severe and sometimes fatal haemorrhage.

• Dasatinib+alteplase- Using dasatinib together with alteplase may increase the risk of bleeding. The interaction may be more likely if you are elderly or have kidney or liver disease. In clinical studies, treatment with dasatinib alone has been associated with severe and sometimes fatal haemorrhage. Talk to your doctor if you have any questions or concerns.

• Dasatinib+anistreplase- Using dasatinib together with anistreplase may increase the risk of bleeding. The interaction may be more likely if you are elderly or have kidney or liver disease. In clinical studies, treatment with dasatinib alone has been associated with severe and sometimes fatal haemorrhage.

• Dasatinib+bepridil- Using bepridil together with dasatinib can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances.

• Dasatinib+dofetilide- Using dofetilide together with dasatinib can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be mo


Mechanism of action

Dasatinib belongs to a class of medications called as tyrosine kinase inhibitors. It blocks the action of an abnormal protein that signals cancer cells to multiply, thereby, stopping the growth and spread of cancer cells.


Pregnancy Category : D


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