Details of Zonisamide Salt (Generic Drug)

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Details

Zonisamide is a sulpha drug with anti-convulsant effects. Zonisamide is used together with other anti-convulsant medications to treat partial seizures in adults with epilepsy. You may not be able to take zonisamide if you have ever had a severe allergic to a sulpha drug. To make sure zonisamide is safe for you, tell your doctor if you have liver disease kidney disease stomach flu or illness causing diarrhoea a growth disorder a bone disorder that causes soft or weak bones or low bone mineral density a history of depression, or suicidal thoughts or actions if you have ever had metabolic acidosis (too much acid in your blood) or if you have been on a ketogenic diet (high-fat, high-protein, low-carb). Zonisamide is not approved for use by anyone younger than 18 years old.


Typical Uses

Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulphonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.


Side Effects

Common zonisamide side effects may include decreased sweating, feeling very hot symptoms of metabolic acidosis-loss of appetite, feeling tired, problems with thinking or talking, irregular heartbeats symptoms of a blood cell disorder-fever, chills, body aches, flu symptoms, sores in your mouth and throat symptoms of a kidney stone-severe pain in your stomach or lower back, blood in your urine increased or worsening seizures the first sign of any skin rash, no matter how mild or severe skin reaction-fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.


Drug Interactions

  • Zonisamide+amitriptyline- Zonisamide can cause increased body temperature and decreased sweating, and these effects may be worsened when combined with medications like amitriptyline. Heat stroke and hospitalisation may occur in some people, especially in warm weather and during vigorous exercise. Children are particularly susceptible.
  • Zonisamide+atropine- Zonisamide can cause increased body temperature and decreased sweating, and these effects may be worsened when combined with medications like atropine. Heat stroke and hospitalisation may occur in some people, especially in warm weather and during vigorous exercise. Children are particularly susceptible.
  • Zonisamide+benztropine- Zonisamide can cause increased body temperature and decreased sweating, and these effects may be worsened when combined with medications like benztropine. Heat stroke and hospitalisation may occur in some people, especially in warm weather and during vigorous exercise. Children are particularly susceptible.
  • Zonisamide+cariprazine- Zonisamide can cause increased body temperature and decreased sweating, and these effects may be worsened when combined with medications like cariprazine. Heat stroke and hospitalisation may occur in some people, especially in warm weather and during vigorous exercise. Children are particularly susceptible.


Mechanism of action

Zonisamide is an anticonvulsant that belongs to a group of medicines called sulphonamides. It works by decreasing abnormal electrical activity in the brain.


Pregnancy Category : C


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