Details of Alteplase Salt (Generic Drug)

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Details

Alteplase is used for treating blood clots in the lungs. It is also used to improve heart function and survival following a heart attack. It is also used to improve recovery and reduce disability in certain patients who have had a stroke. It may also be used for other conditions as determined by your doctor. Alteplase is a tissue plasminogen activator (tPA). It works by helping to break down unwanted blood clots. Do not use Alteplase if you have active internal bleeding, history of stroke, recent brain or spinal surgery (within 3 months), a growth in the brain, abnormal formation of blood vessels, or a certain type of bulging blood vessel if you have a heart attack or blood clot in the lung and you also have had recent brain or spinal injury, a history of bleeding problems, or severe uncontrolled high blood pressure etc.


Typical Uses

Alteplase is an injectable drug, given directly into a vein, that is used to treat conditions caused by arterial blood clots including heart attacks, strokes, chest pain at rest (unstable angina), blood clots in the lungs (pulmonary thrombosis or embolus), and other less common conditions involving blood clots. Alteplase is an enzyme that occurs naturally in man and causes blood clots to dissolve. It is a man-made protein manufactured by recombinant DNA technology. The naturally occurring protein, known as tissue plasminogen activator (TPA), is made by ovarian cells from the Chinese hamster. The amount that is given to patients is far greater than the amount naturally made by the body itself.


Side Effects

Some of the side effects of Alteplase include severe allergic reactions (rash hives itching difficulty breathing or swallowing tightness in the chest swelling of the mouth, face, lips, throat, or tongue) change in colour of your fingers or toes, changes in vision, chest pain or pressure, confusion, fainting, one-sided weakness, purple skin colour, severe dizziness or headache, severe muscle aches or pain, severe stomach pain, speech problems or changes symptoms of bleeding (e.g., vomiting blood or vomit that looks like coffee grounds, coughing up blood, blood in the urine, black, red, or tarry stools bleeding from the gums, unusual vaginal bleeding, bruises without a reason or that get bigger any bleeding that is severe or that you cannot stop) symptoms of kidney problems (e.g., not able to pass urine, change in how much urine is passed, blood in the urine, a big weight gain) symptoms of pancreatitis (e.g., severe stomach or back pain, with or without nausea or vomiting).


Drug Interactions

• Alteplase+abciximab- Using abciximab together with alteplase can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time.

• Alteplase+anisindione- Using alteplase together with anisindione can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time.

• Alteplase+bivalirudin- Using alteplase together with bivalirudin can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time.

• Alteplase+enoxaparin- Using alteplase together with enoxaparin may increase the risk of bleeding, including severe and sometimes fatal haemorrhage.

• Alteplase+heparin- Using heparin together with alteplase can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time.


Mechanism of action

Alteplase injection contains the active ingredient alteplase, which is a type of medicine called a tissue-type plasminogen activator, or fibrinolytic. It is used to dissolve abnormal blood clots that have caused a heart attack, stroke or blood clot in the lung (pulmonary embolism).

Blood clots normally only form to stop bleeding that has occurred as a result of injury to the tissues. Sometimes, however, a blood clot can form abnormally within the blood vessels. The clot can then get lodged in a blood vessel, blocking the blood supply to a vital organ such as the heart (causing a heart attack), brain (causing an ischemic stroke) or lungs (causing a pulmonary embolism).

Blood clots are made of red blood cells and platelets bound together with a substance called fibrin. Once they have fulfilled their normal purpose of stopping bleeding, the body dissolves clots by producing another substance called plasmin. Plasmin breaks down fibrin and allows the clots to break up.

Alteplase works by attaching to the fibrin in abnormal blood clots, such as those in the arteries supplying the heart. It then activates the production of plasmin, which causes the clots to disintegrate. This unblocks the blood vessel and allows blood flow to resume to the affected organ.


Pregnancy Category : C


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