Details of Prednisone Salt (Generic Drug)

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Details

Prednisone is a corticosteroid. It prevents the release of substances in the body that cause inflammation. It also suppresses the immune system. Prednisone is used as an anti-inflammatory or an immunosuppressant medication. Prednisone treats many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders. To make sure prednisone is safe for you, tell your doctor if you have any illness that causes diarrhoea liver disease (such as cirrhosis) kidney disease heart disease, high blood pressure, low levels of potassium in your blood a thyroid disorder diabetes a history of malaria tuberculosis osteoporosis glaucoma, cataracts, or herpes infection of the eyes stomach ulcers, ulcerative colitis, or a history of stomach bleeding a muscle disorder such as myasthenia gravis or depression or mental illness. Prednisone can cause low birth weight or birth defects if you take the medicine during your first trimester.


Typical Uses

Prednisone is used to treat conditions such as arthritis, blood disorders, breathing problems, severe allergies, skin diseases, cancer, eye problems, and immune system disorders. Prednisone belongs to a class of drugs known as corticosteroids. It decreases your immune system's response to various diseases to reduce symptoms such as swelling and allergic-type reactions.


Side Effects

Common prednisone side effects may include blurred vision, eye pain, or seeing halos around lights swelling, rapid weight gain, feeling short of breath severe depression, feelings of extreme happiness or sadness, changes in personality or behaviour, seizure (convulsions) bloody or tarry stools, coughing up blood pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate) low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling) or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).


Drug Interactions

  • Prednisone+adalimumab- Using adalimumab together with prednisone may increase the risk of serious and potentially life-threatening infections. Talk to your doctor if you have any questions or concerns.
  • Prednisone+bupropion- Bupropion may rarely cause seizures, and combining it with other medications that can also cause seizures such as prednisone may increase that risk. The interaction may be more likely if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumour or head trauma.
  • Prednisone+ciprofloxacin- Using ciprofloxacin together with prednisone can increase the risk of tendinitis and tendon rupture. This may be more likely to occur in older adults over 60 years of age or those who have received a kidney, heart, and/or lung transplant. Tendon rupture can occur during or up to several months after finishing ciprofloxacin treatment and may require surgery or result in prolonged disability.
  • Prednisone+gatifloxacin- Using gatifloxacin together with prednisone can increase the risk of tendinitis and tendon rupture. This may be more likely to occur in older adults over 60 years of age or those who have received a kidney, heart, and/or lung transplant. Tendon rupture can occur during or up to several months after finishing gatifloxacin treatment and may require surgery or result in prolonged disability.


Mechanism of action

Prednisone is a glucocorticoid receptor agonist. It is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The anti-inflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Prednisone can stimulate secretion of various components of gastric juice. Suppression of the production of corticotrophin may lead to suppression of endogenous corticosteroids. Prednisone has slight mineralocorticoid activity, whereby entry of sodium into cells and loss of intracellular potassium is stimulated. This is particularly evident in the kidney, where rapid ion exchange leads to sodium retention and hypertension.


Pregnancy Category : C


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