Details of Duloxetine Salt (Generic Drug)

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Details

Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may be unbalanced in people with depression. Duloxetine is used to treat major depressive disorder in adults. Duloxetine is also used to treat general anxiety disorder in adults and children who are at least 7 years old. Duloxetine is also used in adults to treat fibromyalgia (a chronic pain disorder), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain). Duloxetine is also used to treat pain caused by nerve damage in adults with diabetes (diabetic neuropathy). To make sure duloxetine is safe for you, tell your doctor if you have liver or kidney disease seizures or epilepsy a bleeding or blood clotting disorder high blood pressure narrow-angle glaucoma bipolar disorder (manic depression) or a history of drug abuse or suicidal thoughts. Do not give duloxetine to anyone younger than 18 years old without the advice of a doctor.


Typical Uses

Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain. This medication may also be used to help treat other painful nerve conditions (neuropathic pain).


Side Effects

Inform your doctor about any worsening symptoms such as mood or behaviour changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Some of the other side effects of duloxetine include a light-headed feeling, like you might pass out blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights easy bruising, unusual bleeding painful or difficult urination liver problems-nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-coloured stools, jaundice (yellowing of the skin or eyes) high levels of serotonin in the body-agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhoea, loss of coordination, fainting low levels of sodium in the body-headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady severe nervous system reaction-very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors or severe skin reaction-fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Older adults may be more sensitive to the side effects of this medicine.


Drug Interactions

• Duloxetine+alfentanil- Using alfentanil together with duloxetine can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhoea. Severe cases may result in coma and even death.

• Duloxetine+amoxapine- Using amoxapine together with duloxetine can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhoea. Severe cases may result in coma and even death.

• Duloxetine+brexpiprazole- Duloxetine may increase the blood levels of brexpiprazole. This can make you more likely to develop side effects such as drowsiness, seizure, Parkinson-like symptoms, abnormal muscle movements, and low blood pressure. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.

• Duloxetine+desipramine- Using desipramine together with duloxetine can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhoea. Severe cases may result in coma and even death.


Mechanism of action

Duloxetine belongs to a class of drugs called as selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). It increases the levels of chemicals serotonin and norepinephrine in the brain that usually decrease in diseases like depression.


Pregnancy Category : C


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