Details of Desmopressin Salt (Generic Drug)

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Details

Desmopressin is a man-made form of a hormone that occurs naturally in the pituitary gland. This hormone is important for many functions including blood flow, blood pressure, kidney function, and regulating how the body uses water. Desmopressin is used to treat bed-wetting, central cranial diabetes insipidus, and increased thirst and urination caused by head surgery or head trauma. Before taking desmopressin, tell your doctor if you are allergic to any medications, or if you have heart disease, coronary artery disease congestive heart failure kidney disease cystic fibrosis high or low blood pressure an electrolyte imbalance or a psychological disorder that causes extreme or unusual thirst. To be sure desmopressin is helping your condition your blood will need to be tested often. This will help your doctor determine how long to treat you with this medication.


Typical Uses

Desmopressin is used to control the amount of urine your kidneys make. Normally, the amount of urine you make is controlled by a certain substance in the body called vasopressin. In people who have "water diabetes" (diabetes insipidus) or certain kinds of head injury or brain surgery, the body does not make enough vasopressin. Desmopressin is a man-made form of vasopressin and is used to replace a low level of vasopressin. This medication helps to control increased thirst and too much urination due to these conditions, and helps prevent dehydration. Desmopressin is also used to control bleeding caused by surgery or injuries in people with certain bleeding problems (haemophilia A, type 1 von Willebrand disease). It works by helping the body with normal blood clotting.


Side Effects

Stop taking desmopressin and inform your doctor immediately if you experience nausea, vomiting, weakness, loss of appetite, headache, feeling restless or irritable, confusion, hallucinations, muscle pain or weakness, or seizure feeling like you might pass out swelling, weight gain or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).


Drug Interactions

• Desmopressin+alfentanil- Alfentanil can sometimes enhance the effects of desmopressin. Although not common, this may increase the risk of developing water retention and a condition known as hyponatremia, which is caused by an abnormal decrease in blood sodium concentration. In serious cases, hyponatremia can lead to seizure, coma, or even death.

• Desmopressin+bromfenac- Bromfenac can sometimes enhance the effects of desmopressin. Although not common, this may increase the risk of developing water retention and a condition known as hyponatremia, which is caused by an abnormal decrease in blood sodium concentration. In serious cases, hyponatremia can lead to seizure, coma, or even death.

• Desmopressin+buprenorphine- Buprenorphine can sometimes enhance the effects of desmopressin. Although not common, this may increase the risk of developing water retention and a condition known as hyponatremia, which is caused by an abnormal decrease in blood sodium concentration. In serious cases, hyponatremia can lead to seizure, coma, or even death.

• Desmopressin+celecoxib- Celecoxib can sometimes enhance the effects of desmopressin. Although not common, this may increase the risk of developing water retention and a condition known as hyponatremia, which is caused by an abnormal decrease in blood sodium concentration. In serious cases, hyponatremia can lead to seizure, coma, or even death.


Mechanism of action

Desmopressin is a synthetic hormone which has an action similar to naturally occurring anti-diuretic hormone, vasopressin. Desmopressin replaces this naturally occurring hormone, vasopressin in body and helps in maintaining the salt-water balance.


Pregnancy Category : B


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