Details of Cyclosporine Salt (Generic Drug)



Cyclosporine lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader. Cyclosporine is used to prevent organ rejection after a kidney, heart, or liver transplant. Cyclosporine is also used to treat severe psoriasis or severe rheumatoid arthritis. You may not be able to use cyclosporine if you have kidney disease, untreated or uncontrolled hypertension (high blood pressure), any type of cancer, or psoriasis that has been treated with PUVA, UVB, radiation, methotrexate (Trexall), or coal tar. Cyclosporine can lower blood cells that help your body fight infections, or cause your body to produce too much of a certain type of white blood cells. This can lead to serious and sometimes fatal conditions, including cancer, a severe brain infection that can lead to disability or death, or a virus that can cause failure of a transplanted kidney.

Typical Uses

Cyclosporine is used to prevent organ rejection in people who have received a liver, kidney, or heart transplant. It is usually taken along with other medications to allow your new organ to function normally. Cyclosporine is also used to treat severe rheumatoid arthritis and a certain skin condition (severe psoriasis). Cyclosporine belongs to a class of drugs known as immunosuppressants. It works by slowing down your body's defence system (immune system) to prevent your body from rejecting a transplanted organ, further damaging your joints (in rheumatoid arthritis patients), or further damaging your skin (in psoriasis patients). For the treatment of psoriasis or arthritis, it is generally used to treat people who cannot take other medications or have not found relief from other treatments. Cyclosporine may also be used to prevent rejection in other types of organ transplants (e.g., cornea, pancreas) or bone marrow transplant. It may also be used to treat other conditions that may be helped by affecting the immune system (e.g., Crohn's disease).

Side Effects

Some of the side effects of cyclosporine include change in your mental state, problems with speech or walking, decreased vision (may start gradually and get worse quickly) easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin pale or yellowed skin, dark coloured urine, fever, confusion or weakness dangerously high blood pressure-severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats high potassium-nausea, slow or unusual heart rate, weakness, loss of movement kidney problems-little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath liver problems-nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-coloured stools, jaundice (yellowing of the skin or eyes) or signs of infection-fever, chills, flu-like symptoms, mouth sores, skin sores, feeling light-headed or short of breath, rapid heart rate.

Drug Interactions

• Cyclosporine+adalimumab- Using adalimumab together with cyclosporine may increase the risk of serious and potentially life-threatening infections. Talk to your doctor if you have any questions or concerns.

• Cyclosporine+aliskiren- Using aliskiren together with cyclosporine is not recommended. Combining these medications can significantly increase the blood levels and effects of aliskiren. This may cause an excessive fall in blood pressure and increase the risk of a condition called hypercalcemia (high blood potassium), which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest.

• Cyclosporine+cisapride- Using cisapride together with cyclosporine is not recommended. Combining these medications may significantly increase the blood levels of cisapride. High blood levels of cisapride can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances.

• Cyclosporine+edoxaban- Cyclosporine may increase the blood levels of edoxaban. This can increase the risk of serious or life-threatening bleeding complications. Talk to your doctor if you have any questions or concerns.

Mechanism of action

Cyclosporine works by suppressing the body’s immune system. Although this suppression can make it slightly harder for you to fight off infections, it also stabilizes the immune system if it is overactive.

Pregnancy Category : C

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