Details of Capecitabine Salt (Generic Drug)

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Details

Capecitabine is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body. Capecitabine is used to treat colon cancer, and breast or colorectal cancer that has spread to other parts of the body. Capecitabine is often used in combination with other cancer medications or radiation treatments. To make sure capecitabine is safe for you, tell your doctor if you have kidney disease bleeding or blood clotting disorder such as haemophilia liver disease a history of coronary artery disease or if you take a blood thinner. Do not use capecitabine if you are pregnant. It could harm the unborn baby.


Typical Uses

Capecitabine is used alone or with other treatments/medications to treat certain types of cancer (e.g., of the breast, colon and rectum). It works by slowing or stopping cancer cell growth and by decreasing tumour size.


Side Effects

Capecitabine may have certain side effects. Some of them include fever above 100.5 degrees nausea, loss of appetite, eating much less than usual, vomiting (more than once in 24 hours) severe diarrhoea (more than 4 times per day, or during the night) blisters or ulcers in your mouth, red or swollen gums, trouble swallowing, pain, tenderness, redness, swelling, blistering, or peeling skin on your hands or feet dehydration symptoms-feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin heart problems-chest pain or pressure, uneven heartbeats, shortness of breath (even with mild exertion), swelling or rapid weight gain kidney problems-little or no urinating painful or difficult urination swelling in your feet or ankles feeling tired or short of breath liver problems-nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-coloured stools, jaundice (yellowing of the skin or eyes) etc.


Drug Interactions

• Capecitabine+adalimumab- Using adalimumab together with capecitabine may increase the risk of serious and potentially life-threatening infections. Talk to your doctor if you have any questions or concerns.

• Capecitabine+BCG- If you are currently being treated or have recently been treated with capecitabine, you should talk to your doctor before receiving BCG. Depending on the dose and length of time you have been on capecitabine, you may be at risk for developing an infection from the vaccine or have a reduced response to the vaccine.

• Capecitabine+deferiprone- Deferiprone can lower white blood cell count, and combining it with other medications that can also affect bone marrow function such as capecitabine may increase the risk. You may be more likely to develop serious and potentially life-threatening infections as a result.

• Capecitabine+infliximab- Using infliximab together with capecitabine may increase the risk of serious and potentially life-threatening infections. Talk to your doctor if you have any questions or concerns.

• Capecitabine+leucovorin- Products containing folic acid may increase the effects of capecitabine. You may be more likely to develop serious side effects such as anaemia, bleeding problems, infections, and nerve damage when these medications are used together.


Mechanism of action

Capecitabine belongs to a class of medication called cytostatic agents which is an antineoplastic/anticancer prodrug (gets converted into an active substance once into the body). Capecitabine, after being absorbed by the body changes into an active anticancer agent which is more active in the tumour tissue cells than in the normal cells, and thus, stops the growth of cancer cells and slows down the spread of cancer in the body.


Pregnancy Category : D


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