Details of Nicotine Salt (Generic Drug)

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Details

Nicotine is the primary ingredient in tobacco products. Nicotine gum and lozenges are medical products used to aid in smoking cessation in adults. Using a controlled amount of nicotine helps reduce nicotine withdrawal symptoms when you quit smoking. Do not smoke or use other nicotine products (including snuff, chewing tobacco, patches, inhaler, or nasal spray) while you are using nicotine gum or lozenges. Ask a doctor if it is safe for you to use nicotine gum or lozenges if you have heart disease, heart rhythm disorder untreated or uncontrolled high blood pressure diabetes stomach ulcer a history of seizures a food allergy if you have recently had a heart attack if you are on a low salt diet or if you are using any other smoking cessation medicine.


Typical Uses

Nicotine can help you quit smoking by replacing the nicotine in cigarettes. The nicotine in tobacco is an important part of cigarette addiction. When you stop smoking, your nicotine levels drop quickly. This drop can cause withdrawal symptoms such as craving tobacco, nervousness, irritability, headache, weight gain, and difficulty concentrating. Using the inhaler can replace the hand-to-mouth habit of smoking.


Side Effects

Common nicotine side effects may include fast or pounding heartbeats, fluttering in your chest blisters inside your mouth problems with your teeth or jaw or wheezing, tightness in your chest, trouble breathing.


Drug Interactions

  • Nicotine+bupropion- Using bupropion and nicotine together can cause an increase in blood pressure. This can cause dizziness, confusion, uneven heartbeats, and chest pain. If you take both medications together, tell your doctor if you have any of these symptoms.
  • Nicotine+ergotamine- Nicotine may increase the effects of ergotamine in narrowing the blood vessels and decreasing blood flow. A severe decrease in blood flow to the brain and other parts of the body can lead to dangerous side effects.
  • Nicotine+hydroxyprogesterone- Hydroxyprogesterone may reduce the blood levels and effects of nicotine. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.
  • Nicotine+varenicline- Using nicotine together with varenicline can cause an increase in side effects. Contact your doctor if you experience nausea, headache, vomiting, dizziness, and fatigue. You may need a dose adjustment or special test if you use both medications.


Mechanism of action

Nicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed up of five homomeric or heteromeric subunits. In the brain, nicotine binds to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. This causes the channel to open and allow conductance of multiple cations including sodium, calcium, and potassium. This leads to depolarization, which activates voltage-gated calcium channels and allows more calcium to enter the axon terminal. Calcium stimulates vesicle trafficking towards the plasma membrane and the release of dopamine into the synapse. Dopamine binding to its receptors is responsible the euphoric and addictive properties of nicotine. Nicotine also binds to nicotinic acetylcholine receptors on the chromaffin cells in the adrenal medulla. Binding opens the ion channel allowing influx of sodium, causing depolarization of the cell, which activates voltage-gated calcium channels. Calcium triggers the release of epinephrine from intracellular vesicles into the bloodstream, which causes vasoconstriction, increased blood pressure, increased heart rate, and increased blood sugar.


Pregnancy Category : D


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