Details of Methotrexate Salt (Generic Drug)



Methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. It is also used to treat severe psoriasis and rheumatoid arthritis. Methotrexate is usually given after other medications have been tried without successful treatment of symptoms. You should not use this medicine if you are allergic to methotrexate. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have alcoholism, cirrhosis, or other liver disease a blood cell disorder such as anaemia (lack of red blood cells) or leucopoenia (lack of white blood cells) a bone marrow disorder or if you are breast-feeding a baby. To make sure methotrexate is safe for you, tell your doctor if you have kidney disease a folate deficiency pneumonia or lung disease stomach ulcers any type of infection or if you are receiving radiation treatments.

Typical Uses

Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis that has not responded to other treatments. It may also be used to control juvenile rheumatoid arthritis. Methotrexate belongs to a class of drugs known as anti-metabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system. This medication may also be used for lupus and psoriatic arthritis.

Side Effects

Stop using methotrexate and inform your doctor immediately if you have dry cough, shortness of breath diarrhoea, vomiting, white patches or sores inside your mouth or on your lips blood in your urine or stools swelling, rapid weight gain, little or no urinating seizure (convulsions) fever, chills, body aches, flu symptoms pale skin, easy bruising, unusual bleeding, weakness, feeling light-headed or short of breath liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-coloured stools, jaundice (yellowing of the skin or eyes) or severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Drug Interactions

  • Methotrexate+aspirin- Talk to your doctor before using methotrexate and aspirin. This combination may increase the effects of methotrexate in your body. This combination may cause nausea, vomiting, diarrhoea, sore throat, chills, fever, rash, unusual bruising or bleeding, pale skin, dark urine, swelling of the extremities, or shortness of breath.
  • Methotrexate+acitretin- Using methotrexate and acitretin is not recommended. Taking these drugs together may cause liver problems. Acitretin can cause severe, life-threatening birth defects if the mother takes the medication during pregnancy. Never use acitretin if you are pregnant.
  • Methotrexate+bacampicillin- Talk to your doctor before using methotrexate together with bacampicillin. Medications like bacampicillin, especially when given at high dosages for serious infections, can sometimes increase the blood levels and effects of methotrexate. You may have increased side effects such as nausea, vomiting, mouth ulcers, and low blood cell counts, which can make you more likely to develop anaemia, bleeding problems, and infections.
  • Methotrexate+deferasirox- Talk to your doctor before using deferasirox together with methotrexate. Deferasirox may cause kidney problems, and combining it with other medications that can also affect the kidney such as methotrexate may increase that risk. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.

Mechanism of action

Methotrexate belongs to a class of drugs known as anti-metabolites. Methotrexate is referred to as a cytotoxic, most commonly used to stop the growth of cells in tumours. It acts by decreasing the activity of the immune system by blocking several enzymes involved in the immune system and affects the growth of cancerous cells.

Pregnancy Category : X

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