Details of Leflunomide Salt (Generic Drug)

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Details

Leflunomide affects the immune system and reduces swelling and inflammation in the body. Leflunomide is used to treat the symptoms of rheumatoid arthritis. Leflunomide also helps reduce joint damage and improves physical functioning. Do not use leflunomide if you are pregnant or may become pregnant. You will need to have a negative pregnancy test before starting this treatment. To make sure leflunomide is safe for you, tell your doctor if you have a history of liver disease or hepatitis (leflunomide can cause severe liver problems) kidney disease a severe or uncontrolled infection nerve problems, such as neuropathy caused by diabetes a history of tuberculosis a weak immune system or bone marrow disorder or if you are using any drugs that weaken your immune system (such as cancer medicine or steroids). If a man fathers a child during or after leflunomide treatment, the baby may have birth defects.


Typical Uses

Leflunomide is used to treat rheumatoid arthritis, a condition in which the body's defence system (immune system) fails to recognize the body as itself and attacks the healthy tissues around the joints. Leflunomide helps to reduce the joint damage/pain/swelling and helps you to move better. It works by weakening your immune system and decreasing swelling (inflammation). This drug may also be used to prevent rejection of organ transplant.


Side Effects

Some of the side effects of leflunomide include fever, swollen glands, body aches, flu symptoms pale skin, easy bruising or bleeding numbness, tingling, or burning pain in your hands or feet upper stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes) new or worsening cough with fever, trouble breathing or severe skin reaction-fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.


Drug Interactions

  • Leflunomide+abacavir- Leflunomide may cause liver problems, and using it with other medications that can also affect the liver such as abacavir may increase that risk. Because leflunomide can stay in your blood for a prolonged period after the last dose, interactions with other drugs may occur for some time even after you have stopped taking it.
  • Leflunomide+acetaminophen- Leflunomide may cause liver problems, and using it with other medications that can also affect the liver such as acetaminophen may increase that risk. Because leflunomide can stay in your blood for a prolonged period after the last dose, interactions with other drugs may occur for some time even after you have stopped taking it. You should avoid or limit the use of alcohol while being treated with these medications.
  • Leflunomide+aspirin- Leflunomide may cause liver damage and taking it with other medications that can also affect the liver such as aspirin may increase that risk. You should avoid or limit the use of alcohol while being treated with these medications.
  • Leflunomide+bromfenac- Leflunomide may cause liver damage and taking it with other medications that can also affect the liver such as bromfenac may increase that risk. You should avoid or limit the use of alcohol while being treated with these medications.
  • Leflunomide+diclofenac- Leflunomide may cause liver damage and taking it with other medications that can also affect the liver such as diclofenac may increase that risk. You should avoid or limit the use of alco


Mechanism of action

Leflunomide belongs to group of medicines called anti-rheumatic drugs. It reduces inflammation by suppressing the activity of immune cells (lymphocytes) responsible for the inflammation.


Pregnancy Category : X


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