Details of Isotretinoin Salt (Generic Drug)

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Details

Isotretinoin is a form of vitamin A. It reduces the amount of oil released by oil glands in your skin, and helps your skin renew itself more quickly. Isotretinoin is used to treat severe nodular acne that has not responded to other treatments, including antibiotics. You must have a negative pregnancy test before taking isotretinoin. Isotretinoin in just a single dose can cause severe birth defects or death of a baby. Never use this medicine if you are pregnant or may become pregnant. To make sure isotretinoin is safe for you, tell your doctor if you have a history of depression or mental illness asthma liver disease diabetes heart disease or high cholesterol osteoporosis or low bone mineral density an eating disorder such as anorexia an intestinal disorder such as inflammatory bowel disease, ulcerative colitis, or Crohn's disease or a food or drug allergy.


Typical Uses

Isotretinoin is used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatment (e.g., benzoyl peroxide or clindamycin applied to the skin or tetracycline or minocycline taken by mouth). It belongs to a class of drugs known as retinoids. It works by decreasing facial oil (sebum) production. High amounts of sebum can lead to severe acne. If left untreated, severe acne may cause permanent scarring. This medication may also be used to treat a certain type of cancer (neuroblastoma). Isotretinoin is not approved for use by anyone younger than 12 years old.


Side Effects

Stop using isotretinoin and inform your doctor if you experience problems with your vision or hearing severe headache, dizziness, seizure (convulsions), sudden numbness or weakness depressed mood, sleep problems, crying spells, changes in behaviour, feeling aggressive or irritable hallucinations, (see or hearing things that are not real), thoughts about suicide or hurting yourself muscle weakness, pain in your bones or joints or in your back severe diarrhoea, rectal bleeding, bloody or tarry stools pale skin, feeling light-headed or short of breath dark urine, or jaundice (yellowing of your skin or eyes) severe stomach or chest pain, pain when swallowing or severe skin reaction.


Drug Interactions

  • Isotretinoin+bexarotene- Using bexarotene together with isotretinoin may increase the risk of pancreatitis, or inflammation of the pancreas. Talk to your doctor if you have any questions or concerns.
  • Isotretinoin+leflunomide- Leflunomide may cause liver problems and using it with other medications that can also affect the liver such as isotretinoin may increase that risk. Because leflunomide can stay in your blood for a prolonged period after the last dose, interactions with other drugs may occur for some time even after you have stopped taking it. You should avoid or limit the use of alcohol while being treated with these medications.
  • Isotretinoin+lomitapide- Lomitapide may cause liver problems and using it with other medications that can also affect the liver such as isotretinoin may increase that risk. You should avoid or limit the use of alcohol to no more than one drink per day while being treated with these medications.
  • Isotretinoin+tetracycline- Using tetracycline together with isotretinoin is not recommended. Combining these medications may increase the risk of a rare but potentially serious condition caused by increased pressure in the brain. In some cases, this can lead to permanent vision loss.


Mechanism of action

Isotretinoin belongs to a class of medication called retinoids (forms of vitamin A). It works by decreasing the amount of oil secreted by oil glands thus helping the skin to renew quickly.


Pregnancy Category : X


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