Parkinson's disease is a degenerative disease of the central nervous system, which affects the motor system. The cause of the disease is mainly unknown, but it is due to the death of the cells in a portion of mid-brain. Collection of mis-folded protein in the brain witch can't be degraded due to certain mutation is other genes in the Lewy bodies of the neurons, which doesn't allow the motor neuron to work properly. Lewy bodies are abnormal circular structure which are found in the cytoplasm of the neuron cells.
- Parkinson's mostly occur to 1 percent population to person mostly above 65 years of age.
- In 2015, PD affected 6.2 million people, with 117,400 deaths worldwide.
- Here, nerve cells don't produce enough of chemical, which is dopamine.
- With adverse of this disease, people have trouble in walking, talking or doing simple things
- Even there are events of depression, anxiety, stress etc.
Symptoms of Parkinson's disease:
Diagnosing the symptoms of Parkinson may be very difficult, as it can often be misguided with other diseases.
- Early symptoms may include:
- Tremor or shaking
- Loss of smell
- Trouble moving or walking
- Trouble sleeping
- Small handwriting
- Stooping or hunching over (can't stand straight)
- Masked face
- Soft and low voice
- With increase in PD, certain chronic symptoms can be seen such as:
- tremor of the hands, arms, legs, jaw and face
- bradykinesia or slowness of movement
- rigidity or stiffness of the limbs and trunk
- postural instability or impaired balance and coordination
Causes of Parkinson's:
- Causes of Parkinson's are not known.
- But it is mostly caused by genetic factors or environmental conditions.
- Patient having a family history of PD, and exposed to certain toxic chemicals tend to have a higher than others.
Risk factors of Parkinson's disease:
- In PD, males are more affected than females.
- Person of mostly above 65 years of age are more affected by PD.
- People exposed to pesticides and having a prior head injury are more risk to PD.
- Having a family person with PD, can be the most cause a risk for Parkinson's disease
Treatments of Parkinson's:
- There is no particular treatment for Parkinson's disease.
- As a initial treatment, certain antiparkinson medication L-DOPA (levodopa), with dopamine agonists being used once levodopa becomes less effective.
- As the disease progresses and neurons continue to be lost, these medications become less effective while at the same time they produce a complication marked by involuntary writhing movements.
- Diet and some forms of rehabilitation can show some effectiveness at improving symptoms.
- Surgery to place microelectrodes for deep brain stimulation has been used to reduce motor symptoms in severe cases where drugs are ineffective.1
- Evidence for treatments for the non-movement-related symptoms of PD, such as sleep disturbances and emotional problems, is less strong.
Diagnosis of Parkinson's:
- There is no test to confirm Parkinson's disease.
- A doctor can confirm it by knowing the person's family history and by some neurological tests.
Patients of Parkinson's undergo certain disturbance and emotional up downs. Support from family is the most important treatment for them.