Hi Guest                                                     

Full Body Health Checkup I
Price Rs. 2200.00
Discount Rs. 0.00
Payable Rs.2200.00
Book Now
Vitamin Panel
Price Rs. 3245.00
Discount Rs. 486.75
Payable Rs.2758.25
Book Now
Comprehensive Wellness (Advance)
Price Rs. 6850.00
Discount Rs. 1027.50
Payable Rs.5822.50
Book Now
Learn more about diseases
Total Views: 7,571
Mandibulofacial Dysostosis
Posted on Feb 06, 2016
Mandibulofacial Dysostosis is a disorder characterized by deformities of the facial bones and skull. It is a rare type of syndrome which is inherited as an autosomal dominant disease. The condition generally presents with a narrow face, small lower jaw and lack of prominent cheek bones. The condition is present since birth and may be associated with other anomalies involving the ears, eyelids, palate and throat. The condition is chiefly associated with underdevelopment of facial bone structure. It is also known as Treacher-Collins syndrome and Treacher Collins-Franceschetti syndrome.

Causes of Mandibulofacial Dysostosis

Mandibulofacial dysostosis is an inherited disease associated with a genetic mutation. The disease has no specific predilection for any race and is found affecting males and females equally. The gene mutation is caused by defect in TCOF1 gene. Parents with mutated genes transmit the disease to their offspring. The disease may be very mild or undiagnosed in the parent in some cases.

The disease occurs in around 1 of every 25,000 to 50,000 births. The disease shows more severe symptoms in subsequent generations in a family suffering from mandibulofacial dysostosis. The syndrome manifest at birth and can be diagnosed by clinical symptoms, X-rays, ultrasounds and CT scans.
The severity of the symptoms of mandibulofacial dysostosis varies in different patients. The characteristic facial structure is similar in most of the patients with various degrees of deformity. The face is narrow at the lower third due to narrow and small lower jaws. The chin is retruded with presence of a prominent notch. The small size of jaws leads to orthodontic problems such as malocclusion.

Other dental problems include absence of teeth or malformed tooth enamel. In one-third of mandibulofacial dysostosis cases cleft palate is present. Absence of salivary glands such as parotid glands may also be associated with the disease. A notch like depression is present on the lower aspect of eyelids. The eyelashes are scanty or absent in most of the cases. Loss of vision can occur in severe cases with eye deformity. Defects in nasal bones may also be present.

Both inner and outer ears are deformed in mandibulofacial dysostosis. The pinnae are deformed with or without extra ear tags. Defects in the inner ear can lead to deafness. Presence of hypoplastic pharynx and narrowed wind pipe associated with mandibulofacial dysostosis can be lethal in infants. The condition can lead to difficulty in feeding and breathing.
Mild forms of mandibulofacial dysostosis may not require specific treatment except for correction of dental problems and improvement of overall deformed structures. In cases with moderate to severe deformities surgical approaches are preferred to restore the aesthetics. Cosmetic surgeries for facial reconstruction are advised in severely deformed cases. Various surgeries involving eyes, cheek bone, jaws can be performed at specific ages when the bones fully develop.

Cases with cleft palate should be treated with separate surgical procedure at an early age for closure of the cleft. Orthognathic surgeries are also indicated to correct severe orthodontic problems in adult life. The children with feeding and respiratory problems require immediate attention and may require surgical approaches to maintain the airway.
Mandibulofacial Dysostosis symptoms, Mandibulofacial Dysostosis causes, Mandibulofacial Dysostosis,mandibulofacial dysostosis, symptoms of Treacher Collins Syndrome, causes of Treacher Collins Syndrome, treatment of Treacher Collins Syndrome, genetic mutation disease, deformities of the facial bones, Treacher Collins Syndrome causes, Treacher Collins Syndrome symptoms, Treacher Collins Syndrome diseases, Orthognathic surgery
Read latest diseases...
Narcolepsy symptoms, Narcolepsy  treatment, Narcolepsy causes,narcolepsy, causes of narcolepsy, symptoms of narcolepsy, treatment of narcolepsy, narcolepsy causes, narcolepsy symptoms, narcolepsy treatment, how to deal with narcolepsy, cure for narcolepsy, sleep paralysis, hallucinationsNarcolepsy..Read More
rheumatic fever in children, symptoms of rheumatic fever in children, treatment of rheumatic fever,rheumatic fever in children, symptoms of rheumatic fever in children, treatment of rheumatic fever in children, rheumatic fever in children symptoms, rheumatic fever in children treatment, strep throat, scarlet fever, strep throat infection, skin rash, weight lossRheumatic Fever in Children..Read More
choana atresia causes, treatment of choana atresia, symptoms of choana atresia,choanal atresia, symptoms of choanal atresia, causes of choanal atresia, diagnosis of choanal atresia, treatment of choanal atresia, prevention of choanal atresia, choanal atresia causes, choanal atresia symptoms, choanal atresia diagnosis, choanal atresia treatment, choanal atresia preventionChoanal Atresia..Read More
treatmetn of cirrhosis of the liver, symptoms of cirrhosis of the liver, causes of cirrhosis liver,liver cirrhosis, cirrhosis of the liver, causes of liver cirrhosis, symptoms of liver cirrhosis, treatment of liver cirrhosis, prognosis of liver cirrhosis, stages of liver cirrhosis, liver cirrhosis causes, liver cirrhosis symptoms, liver cirrhosis treatment, liver cirrhosis prognosis, chronic hepatitis, scarring of the tissue in the liverCirrhosis of the Liver..Read More
encephalocele treatment, symptoms of encephalocele, causes of encephalocele,encephalocele, encephaloceles, symptoms of encephaloceles, diagnosis of encephaloceles, causes of encephaloceles, treatment of encephaloceles, encephaloceles causes, encephaloceles symptoms, encephaloceles diagnosis, encephaloceles treatment, neurosurgeonEncephaloceles..Read More
Seborrheic Dermatitis casues, treatment of Seborrheic Dermatitis, symptoms of Seborrheic Dermatitis,seborrheic dermatitis, causes of seborrheic dermatitis, symptoms of seborrheic dermatitis, treatment of seborrheic dermatitis, seborrheic dermatitis causes, seborrheic dermatitis symptoms, seborrheic dermatitis treatment, treating seborrheic dermatitis naturally, seborrheic dermatitis home remedies, home remedies for seborrheic dermatitis, dermatologist, dermatitisSeborrheic Dermatitis..Read More
Search Doctors by Speciality
Best Pediatrician in Delhi
Best Dentist in Delhi
Best Psychiatrist in Delhi
Best Neurologist in Delhi
Best Oncologist in Delhi
Best Acupuncturist in Delhi
Best Chest & Allergy in Delhi
Best Diabetologist in Delhi
Best Physiotherapist in Delhi
Best Gynecologist in Delhi
Best Cardiologist in Delhi
Best Pulmonologist in Delhi
Best Dermatologist in Delhi
Best Dietician in Delhi
Best Endocrinologist in Delhi
Best Nephrologist in Delhi
Best Orthopaedic in Delhi
Best Psychologist in Delhi
Best Homeopathy in Delhi
Best Urologist in Delhi
Best Ayurvedic in Delhi
Best Nutritionist in Delhi
Best Orthopaedic Surgeon in Delhi
Best Plastic-Cosmetic Surgeon in Delhi
Best General Physician in Delhi
Best General Surgeon in Delhi
Best Ear Nose Throat (ENT) in Delhi
Best Gastroenterologist in Delhi
Best Laparoscopic Surgeon in Delhi
Best Ophthalmologist in Delhi
Best General Practitioner in Delhi
Best Dermatologist in Mumbai
Best Dentist in Mumbai
Best Ear Nose Throat (ENT) in Bangalore
Best Gastroenterologist in Bangalore
Best Gynecologist in Noida
Best General Physician in Noida
Best Pediatrician in Noida
Best Plastic Cosmetic Surgeon in Noida
Best Dermatologist in Pune
Best Gynecologist in Navi Mumbai
Best Pediatrician in Bangalore
Best Ophthalmologist in Bangalore
Best Dentist in Gurgaon
Best General Physician in Gurgaon
Best General Practitioner in Gurgaon
Best Ear Nose Throat (ENT) in Gurgaon
Best Gynecologist in Mumbai
Best Gynecologist in Thane
Best Dermatologist in Bangalore
Best Pediatrician in Mumbai
Best Physiotherapist in Faridabad
Best Orthopaedic in Faridabad
Best Dentist in Faridabad
Best Ophthalmologist in Faridabad
Best Gynecologist in Pune
Best Orthopaedic Surgeon in Mumbai
Best General Practitioner in Bangalore
Best Ear Nose Throat (ENT) in Mumbai
Best Orthopaedic Surgeon in Faridabad
Book Diagnostics Tests Delhi/NCR
Book Health Packages Delhi/NCR
About Us
Press Releases
Terms of Use
Privacy Policy
Our Services
DocPractice™ Premium
Health Card
Hospital SignUp
Book Diagnostics Tests Delhi/NCR
Book Health Packages Delhi/NCR
Hospital listing
Diagnostic center
Contact us
Ecommerce Flow / Incorporated
Read Articles
Learn About Diseases
Learn About Diagnostic Tests
Learn About Generic Drugs
Social media
Follow us
Lazoi on Facebook Lazoi on Twitter Lazoi on Google Plus Lazoi on BlogSpot
Make online secure payment using

MasterCard  VISA  NetBanking 
Copyright © 2017 Lazoi Lifecare™ Pvt. Ltd. All rights reserved. Website Version 4.0.0