Waldenstrom Macroglobulinemia (WM)
- Posted on- Oct 15, 2015
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Waldenstrom macroglobulinemia (WM), also known as lymphoplasmacytic lymphoma, is a type of non-Hodgkin lymphoma. It is very uncommon, slow-growing cancer that begins in the immune system. Abnormal white blood cells (lymphocytes) in the bone marrow make an abnormal protein called monoclonal immunoglobulin M (IgM) that thickens the blood plasma. This causes the symptoms of Waldenstrom macroglobulinemia.
Waldenstrom macroglobulinemia cells develop mainly in the bone marrow, where they can crowd out the normal cells that make the different types of blood cells. This can cause low levels of red blood cells, effects of which may make people tired and weak. It can also cause low numbers of white blood cells, which makes it difficult for the body to fight infection.