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Periventricular Leukomalacia (PVL)

  • Posted on- Oct 15, 2015
  • 738 Views

Periventricular leukomalacia (PVL) is a form of brain damage that affects the white matter of brain, resulting in the cells in the white matter of brain either decaying or dying. In turn, an area of the brain is left empty, resulting in fluid build-up. It’s estimated that around 60-100% of all children who have PVL will also develop cerebral palsy. In most cases, spastic diplegia is the most typical type of CP that develops due to PVL. Although uncommon, quadriplegia CP may also develop.

Causes of Periventricular leukomalacia (PVL)
Cell damage to the brain’s periventricular tissue as well as a decrease in blood flow are the two primary reasons that PVL occurs. In addition, babies born prematurely, especially before 32 weeks gestation, have a heightened risk of PVL. Unfortunately, premature infants are also at the highest risk of death should they develop PVL. A host of other conditions can cause Periventricular leukomalacia including:

  • Having twins
  • Umbilical cord inflammation
  • Antepartum haemorrhage
  • Problems with the placental blood vessel
  • Chorioamnionitis
  • Sepsis and other illnesses in which bacteria enters the bloodstream
  • Lack of oxygen to the periventricular area of the infant’s brain

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