- Posted on- Oct 15, 2015
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Sporadic porencephaly is a rare disorder affecting the central nervous system. In porencephaly cysts or cavities form on the surface of the brain. These cysts or cavities may become filled with cerebrospinal fluid, a colourless fluid that normally surrounds the brain and spinal cord to provide protection and nourishment. The severity and associated symptoms of porencephaly vary dramatically from one person to another based upon the size and exact locations of the fluid-filled cavities or cysts.
Porencephaly may be classified as sporadic or familial. Sporadic porencephaly can have many different causes including infection just before or just after birth (perinatal infection), trauma, maternal disease or sickness, maternal diabetes, or maternal use of alcohol or drugs such as cocaine during pregnancy.
Causes of sporadic porencephaly
Sporadic porencephaly is caused by damage to the cerebral hemispheres of the brain, which results in the formation of fluid-filled cavities or cysts on the surface of the brain. Researchers believe that the damage or loss of brain tissue that characterizes porencephaly results from infection interrupted or obstructed blood flow (ischemia) to the brain, or bleeding (haemorrhaging
) in the brain.
A variety of different conditions can potentially cause the localized brain tissue degeneration that ultimately leads to sporadic porencephaly. Such conditions include infection just before or shortly after birth (perinatal infection), too little oxygen in the body just before or shortly after birth (perinatal asphyxia), birth trauma, drug or alcohol use by the mother during pregnancy, maternal sickness or infection, maternal diabetes
, or injury or trauma (particularly to the abdominal area) to the mother during pregnancy.