Primary Ciliary Dyskinesia (PCD)
- Posted on- Oct 15, 2015
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Primary ciliary dyskinesia (PCD) is an autosomal recessive genetic condition in which the microscopic cells in the respiratory system called cilia do not function normally. Ciliary dysfunction prevents the clearance of mucous from the lungs, paranasal sinuses and ears. Bacteria and irritants in the mucous lead to frequent respiratory infections. Kartagener syndrome is a type of Primary ciliary dyskinesia associated with a mirror-image orientation of the heart and other internal organs.
Causes of Primary ciliary dyskinesia (PCD)
Primary ciliary dyskinesia usually follows autosomal recessive genetic inheritance. Recessive genetic disorders occur when an individual inherits the same abnormal gene for the same trait from each parent. If an individual receives one normal gene and one gene for the disease, the person will be a carrier for the disease, but usually will not show symptoms.
All individuals carry multiple abnormal genes for various traits. Parents who are close relatives have a higher chance than unrelated parents to both carry the same abnormal gene, which increases the risk to have children with a recessive genetic disorder.