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Test Details
Test Code:PL0286
Test Name:Vitamin E
Test Details & Preparation
Vitamin E contributes to the normal maintenance of biomembranes the vascular system, and the nervous system, and provides antioxidant protection for vitamin A. The level of vitamin E in the plasma or serum after a 12- to 14-hour fast reflects the individual's reserve status.

Vitamin E is known to promote the formation of prostacyclin in endothelial cells and to inhibit the formation of thromboxanes in thrombocytes, thereby minimizing the aggregation of thrombocytes at the surface of the endothelium. Those influences on thrombocyte aggregation may be of significance in relation to risks for coronary atherosclerosis and thrombosis.

Deficiency of vitamin E in children leads to reversible motor and sensory neuropathies this problem also has been suspected in adults. Premature infants who require an oxygen-enriched atmosphere are at increased risk for bronchopulmonary dysplasia and retrolental fibroplasias supplementation with vitamin E has been shown to lessen the severity of, and may even prevent, those problems.

Deficiencies of vitamin E may arise from poor nutrition or from intestinal malabsorption. At-risk persons, especially children, include those with bowel disease, pancreatic disease, chronic cholestasis, celiac disease, cystic fibrosis, and intestinal lymphangiectasia.

Low blood levels of vitamin E may be associated with abetalipoproteinemia, presumably as a result of a lack of the ability to form very low-density lipoproteins and chylomicrons in the intestinal absorptive cells of affected persons.

Clinical interpretation of values which shows a need for supplementation Premature: <2.0 mg/L Neonate: <2.0 mg/L Child (3 months): <3.0 mg/L Child (2 years): <4.0 mg/L and Adult: <4.0 mg/L.

Testing of non fasting samples or the use of vitamin supplementation can result in elevated plasma vitamin concentrations.
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