vanillylmandelic acid test, VMA, VMA test, VMA Spot Urine test, catecholamine-secreting tumours, neuroblastoma, pheochromocytoma" /> vanillylmandelic acid test, VMA, VMA test, VMA Spot Urine test, catecholamine-secreting tumours, neuroblastoma, pheochromocytoma" />
 
 
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Test Details
Test Code:PL0279
Test Name:Vanil Mandelic Acid (VMA), Spot Urine
Test Details & Preparation
Vanillylmandelic acid (VMA) and other catecholamine metabolites (homovanillic acid HVA and dopamine) are typically elevated in patients with catecholamine-secreting tumours (e.g., neuroblastoma, pheochromocytoma, and other neural crest tumours). VMA and HVA levels may also be useful in monitoring patients who have been treated as a result of one of the above-mentioned tumours.

Vanillylmandelic acid (VMA) and/or homovanillic acid concentrations are elevated in more than 90% of patients with neuroblastoma both tests should be performed. A positive test could be due to a genetic or nongenetic condition. Additional confirmatory testing is required. A normal result does not exclude the presence of a catecholamine-secreting tumour. Elevated VMA values are suggestive of a pheochromocytoma, but they are not diagnostic.

Administration of L-dopa may falsely increase vanillylmandelic acid (VMA) results. Patients receiving L-dopa should stop taking it for 24 hours before and during the collection. All patients receiving L-dopa should be identified to the laboratory when VMA and homovanillic acid (HVA) tests are ordered. Values are more commonly elevated during a hypertensive episode. Values may be normal in some individuals with a pheochromocytoma. Bactrim may interfere with detection of the analyte. All patients taking Bactrim should be identified to the laboratory when VMA and HVA tests are ordered.
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