Brain SPECT imaging, SPECT Cerebral Perfusion Scan, cerebro-vascular disease, functional nuclear imaging, cerebral perfusion" /> Brain SPECT imaging, SPECT Cerebral Perfusion Scan, cerebro-vascular disease, functional nuclear imaging, cerebral perfusion" />
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Test Details
Test Code:NM0033
Test Name:SPECT Cerebral Perfusion Scan (Pre and Post Diamox Intervention Study)
Test Details & Preparation
Brain perfusion single-photon emission computed tomography (SPECT) imaging is a functional nuclear imaging technique performed to evaluate regional cerebral perfusion. Because cerebral blood flow is closely linked to neuronal activity, the activity distribution is presumed to reflect neuronal activity levels in different areas of the brain. A lipophilic, PH-neutral radiopharmaceutical is injected into the patient, which crosses the blood-brain barrier and continues to emit gamma rays. A 3-dimensional representation of cerebral blood flow can be iterated using gamma detectors, allowing for interpretation. Brain SPECT can be complemented with pharmaceutical agents that enhance regional cerebral blood flow, such as acetazolamide (carbonic anhydrase). Acetazolamide increases local pCO2 and causes arteriolar dilation allowing for assessment of cerebro-vascular reserve in transient ischemic attack, stroke, and vascular anomalies and distinguishing vascular from neuronal causes of dementia. Brain perfusion SPECT imaging can aid in the diagnosis and ongoing evaluation of many different medical conditions such as detection and evaluation of cerebro-vascular disease help in the diagnosis and differential diagnoses of suspected dementia detection of seizure focus assessment of brain death evaluating suspected brain trauma mood disorders, evaluating and subtyping attention-deficit disorder substance abuse and infection/inflammation. Brain SPECT imaging is restricted when an individual is pregnant or breastfeeding. Brain SPECT imaging is a safe procedure on the whole. However, care must be provided by the imaging technologist to reduce patient discomfort and minimize motion artifact. Care must also be provided to avoid tissue extravasation of radiopharmaceutical agents, as there is potential to induce tissue necrosis.
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