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Test Details
Test Code:PL0870
Test Name:Protein-C Activity
Test Details & Preparation
Protein C is a normal substance in the body that prevents blood clotting. A blood test can be done to see how much of this protein you have in your blood. You will have a sample of blood taken from a vein.

Certain drugs can interfere with this test. Be sure to tell your doctor about all medicines and supplements you are taking before having this test. Some medicines that prevent blood clots from forming (anticoagulants), such as warfarin (Coumadin) decrease protein C and protein S levels. Your doctor may ask you to stop taking these medicines for a time before the test.

You may feel slight pain or a sting when the needle is inserted to draw blood. You may feel some throbbing afterward.

You may need this test if you have an unexplained blood clot, or a family history of blood clots. Protein C and protein S help regulate blood clotting. A lack of these proteins or problem with the function of these proteins may cause blood clots to form in veins. The test is also used to screen relatives of patients with a known protein C deficiency. It may also be done to find the reason for repeated miscarriages.

Normal values are 60 - 150% inhibition. Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

A lack (deficiency) of protein C can lead to excess clotting. These clots tend to form in veins, not arteries. Protein C deficiency can be passed down through families (inherited) or it can develop with other conditions, such as chemotherapy use disseminated intravascular coagulation (DIC) liver disease long-term antibiotic use and Warfarin (Coumadin) use. Protein C levels rise with age, but this does not cause any health problems.
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