• Test Code - PL0848
  • Test Name - PAPP A (Pregnancy Associated Plasma Protein A)
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Test Details & Preparation


  • PAPP A (Pregnancy Associated Plasma Protein A) test is done to assess the risk of a foetus having a chromosomal abnormality, such as Down syndrome (trisomy 21) or Edwards’s syndrome (trisomy 18).

  • PAPP A (Pregnancy Associated Plasma Protein A) test is performed normally between 11 and 14 weeks of pregnancy.

  • A blood sample drawn from a vein in your arm or a blood spot collected on special paper from a finger stick a nuchal translucency requires a special ultrasound exam.

  • You may be instructed to have a full bladder when having the nuchal translucency ultrasound performed.

  • A mathematical calculation using the results obtained from the PAPP-A, HCG, and nuchal translucency ultrasound is used to determine a numeric risk of a chromosomal defect in the foetus.

  • In pregnancies where the foetus is carrying a chromosomal defect, such as the extra chromosome material that results in Down syndrome or Edwards syndrome, the levels of PAPP-A tend to be decreased, the levels of hCG are significantly increased, and the space at the foetus’s neck is larger than normal.

  • If a screening test is positive, more definitive tests are needed to determine and confirm a diagnosis.


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